Thioredoxin-Interacting Protein Mediates Sustained VEGFR2 Signaling in Endothelial Cells Required for Angiogenesis | Zendy

ShinYoung Park | Zendy; Xi Shi | Zendy; Jinjiang Pang | Zendy; Chen Yan | Zendy; Bradford C. Berk | Zendy

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Thioredoxin-Interacting Protein Mediates Sustained VEGFR2 Signaling in Endothelial Cells Required for Angiogenesis

Author(s) -

ShinYoung Park,

Xi Shi,

Jinjiang Pang,

Chen Yan,

Bradford C. Berk

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300386

Subject(s) - thioredoxin interacting protein , txnip , angiogenesis , phosphorylation , microbiology and biotechnology , endothelial stem cell , biology , signal transduction , protein kinase b , human umbilical vein endothelial cell , vascular endothelial growth factor a , cancer research , vascular endothelial growth factor , chemistry , biochemistry , thioredoxin , oxidative stress , vegf receptors , in vitro

Thioredoxin-interacting protein (TXNIP) is an α-arrestin protein whose function is important for the regulation of vascular endothelial growth factor receptor 2 (VEGFR2) signaling and endothelial cell survival. Because VEGFR2 is critical for angiogenesis, we explored the role of TXNIP in VEGF-induced angiogenesis.

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