Increased Interstitial Protein Because of Impaired Lymph Drainage Does Not Induce Fibrosis and Inflammation in Lymphedema | Zendy

Carl Erik Markhus | Zendy; Tine V. Karlsen | Zendy; Marek Wagner | Zendy; Øyvind S. Svendsen | Zendy; Olav Tenstad | Zendy; Kari Alitalo | Zendy; Helge Wiig | Zendy

Open Access

Increased Interstitial Protein Because of Impaired Lymph Drainage Does Not Induce Fibrosis and Inflammation in Lymphedema

Author(s) -

Carl Erik Markhus,

Tine V. Karlsen,

Marek Wagner,

Øyvind S. Svendsen,

Olav Tenstad,

Kari Alitalo,

Helge Wiig

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300384

Subject(s) - lymphedema , inflammation , fibrosis , medicine , lymph , pathology , cancer , breast cancer

The pathophysiology of lymphedema is incompletely understood. We asked how transcapillary fluid balance parameters and lymph flow are affected in a transgenic mouse model of primary lymphedema, which due to an inhibition of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling lacks dermal lymphatics, and whether protein accumulation in the interstitium occurring in lymphedema results in inflammation.

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