Krüppel-Like Factor-11, a Transcription Factor Involved in Diabetes Mellitus, Suppresses Endothelial Cell Activation via the Nuclear Factor-κB Signaling Pathway | Zendy

Yanbo Fan | Zendy; Yanhong Guo | Zendy; Jifeng Zhang | Zendy; Malayannan Subramaniam | Zendy; Chao-Zhong Song | Zendy; Raúl Urrutia | Zendy; Y. Eugene Chen | Zendy

Open Access

Krüppel-Like Factor-11, a Transcription Factor Involved in Diabetes Mellitus, Suppresses Endothelial Cell Activation via the Nuclear Factor-κB Signaling Pathway

Author(s) -

Yanbo Fan,

Yanhong Guo,

Jifeng Zhang,

Malayannan Subramaniam,

Chao-Zhong Song,

Raúl Urrutia,

Y. Eugene Chen

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300349

Subject(s) - proinflammatory cytokine , transcription factor , cell adhesion molecule , gene knockdown , tumor necrosis factor alpha , microbiology and biotechnology , signal transduction , cell adhesion , endothelial stem cell , biology , inflammation , cancer research , chemistry , medicine , immunology , cell , biochemistry , apoptosis , gene , in vitro

Endothelial cell (EC) inflammatory status is critical to many vascular diseases. Emerging data demonstrate that mutations of Krüppel-like factor-11 (KLF11), a gene coding maturity-onset diabetes mellitus of the young type 7 (MODY7), contribute to the development of neonatal diabetes mellitus. However, the function of KLF11 in the cardiovascular system still remains to be uncovered. In this study, we aimed to investigate the role of KLF11 in vascular endothelial inflammation.

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