Open AccessDeletion of FHL2 Gene Impaired Ischemia-Induced Blood Flow Recovery by Modulating Circulating Proangiogenic Cells
Author(s) -
PoHsun Huang,
ChiYu Chen,
Chih-Pei Lin,
ChaoHung Wang,
HsiaoYa Tsai,
Wei-Yuh Lo,
HsinBang Leu,
JawWen Chen,
ShingJong Lin,
PaoHsien Chu
Publication year - 2013
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.112.300318
Subject(s) - angiogenesis , ischemia , neovascularization , hindlimb , arteriogenesis , biology , western blot , medicine , immunology , andrology , pathology , endocrinology , cancer research , gene , biochemistry
The four and a half Lin11, Isl-1 and Mec-3 (LIM) domain protein 2 (FHL2) is a member of the four and a half LIM domain-only (FHL) gene family, and has been shown to play an important role in inhibiting inflammatory angiogenesis. Here, we tested the hypothesis that impaired ischemia-induced neovascularization in mice lacking FHL2 is related to a defect in proangiogenic cell mobilization and functions in vasculogenesis.
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