Apelin/APJ Signaling Is a Critical Regulator of Statin Effects in Vascular Endothelial Cells—Brief Report | Zendy

Danielle L. McLean | Zendy; Jongmin Kim | Zendy; Yujung Kang | Zendy; Hong Shi | Zendy; G. Brandon Atkins | Zendy; Mukesh K. Jain | Zendy; Hyung J. Chun | Zendy

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Apelin/APJ Signaling Is a Critical Regulator of Statin Effects in Vascular Endothelial Cells—Brief Report

Author(s) -

Danielle L. McLean,

Jongmin Kim,

Yujung Kang,

Hong Shi,

G. Brandon Atkins,

Mukesh K. Jain,

Hyung J. Chun

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300317

Subject(s) - apelin , vasoprotective , thrombomodulin , microbiology and biotechnology , signal transduction , endothelial stem cell , klf2 , medicine , biology , chemistry , nitric oxide , endocrinology , downregulation and upregulation , receptor , thrombin , biochemistry , gene , platelet , in vitro

The endothelial response elicited by the G-protein-coupled receptor pathway involving apelin and APJ predicts an overall vasoprotective effect. As a number of downstream endothelial targets of apelin/APJ signaling are also known to be targeted by statins (3-hydroxy-3-methyl-glutaryl [HMG]-CoA reductase inhibitors) as potential mediators of their known pleiotropic effects, we evaluated for the involvement of apelin/APJ signaling in statin endothelial effects.

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