Anti-Inflammatory and Antiatherogenic Role of BMP Receptor II in Endothelial Cells | Zendy

Chan Woo Kim | Zendy; Hannah Song | Zendy; Sandeep Kumar | Zendy; Douglas Nam | Zendy; HyukSang Kwon | Zendy; Kyung Hwa Chang | Zendy; Dong Ju Son | Zendy; Dong Won Kang | Zendy; Seth A. Brodie | Zendy; Daiana Weiss | Zendy; J. David Vega | Zendy; Noah AlbertsGrill | Zendy; Kathy K. Griendling | Zendy; W. Robert Taylor | Zendy; Hanjoong Jo | Zendy

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Anti-Inflammatory and Antiatherogenic Role of BMP Receptor II in Endothelial Cells

Author(s) -

Chan Woo Kim,

Hannah Song,

Sandeep Kumar,

Douglas Nam,

HyukSang Kwon,

Kyung Hwa Chang,

Dong Ju Son,

Dong Won Kang,

Seth A. Brodie,

Daiana Weiss,

J. David Vega,

Noah AlbertsGrill,

Kathy K. Griendling,

W. Robert Taylor,

Hanjoong Jo

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300287

Subject(s) - inflammation , downregulation and upregulation , receptor , microbiology and biotechnology , endothelium , endothelial dysfunction , proinflammatory cytokine , gene knockdown , biology , medicine , endocrinology , immunology , apoptosis , biochemistry , gene

Atherosclerosis is an inflammatory disease with multiple underlying metabolic and physical risk factors. Bone morphogenic protein 4 (BMP4) expression is increased in endothelium in atherosclerosis-prone regions and is known to induce endothelial inflammation, endothelial dysfunction, and hypertension. BMP actions are mediated by 2 different types of BMP receptors (BMPRI and BMPRII). Here, we show a surprising finding that loss of BMPRII expression causes endothelial inflammation and atherosclerosis.

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