Acid Sphingomyelinase Regulates Platelet Cell Membrane Scrambling, Secretion, and Thrombus Formation | Zendy

Patrick Münzer | Zendy; Oliver Borst | Zendy; Britta Walker | Zendy; Evi Schmid | Zendy; Marion A.H. Feijge | Zendy; Judith M.E.M. Cosemans | Zendy; Madhumita Chatterjee | Zendy; EvaMaria Schmidt | Zendy; Sebastian Schmidt | Zendy; Syeda Tasneem Towhid | Zendy; Christina Leibrock | Zendy; Margitta Elvers | Zendy; Martin Schaller | Zendy; Peter Seizer | Zendy; Klaus Ferlinz | Zendy; Andreas E. May | Zendy; Erich Gulbins | Zendy; Johan W. M. Heemskerk | Zendy; Meinrad Gawaz | Zendy; Florian Läng | Zendy

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Acid Sphingomyelinase Regulates Platelet Cell Membrane Scrambling, Secretion, and Thrombus Formation

Author(s) -

Patrick Münzer,

Oliver Borst,

Britta Walker,

Evi Schmid,

Marion A.H. Feijge,

Judith M.E.M. Cosemans,

Madhumita Chatterjee,

EvaMaria Schmidt,

Sebastian Schmidt,

Syeda Tasneem Towhid,

Christina Leibrock,

Margitta Elvers,

Martin Schaller,

Peter Seizer,

Klaus Ferlinz,

Andreas E. May,

Erich Gulbins,

Johan W. M. Heemskerk,

Meinrad Gawaz,

Florian Läng

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300210

Subject(s) - acid sphingomyelinase , ceramide , platelet , phosphatidylserine , platelet activation , thrombus , sphingomyelin , sphingomyelin phosphodiesterase , chemistry , microbiology and biotechnology , lipid signaling , thrombin , biochemistry , immunology , medicine , apoptosis , biology , cholesterol , receptor , phospholipid , membrane

Platelet activation is essential for primary hemostasis and acute thrombotic vascular occlusions. On activation, platelets release their prothrombotic granules and expose phosphatidylserine, thus fostering thrombin generation and thrombus formation. In other cell types, both degranulation and phosphatidylserine exposure are modified by sphingomyelinase-dependent formation of ceramide. The present study thus explored whether acid sphingomyelinase participates in the regulation of platelet secretion, phosphatidylserine exposure, and thrombus formation.

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