Upregulation of a Disintegrin and Metalloproteinase With Thrombospondin Motifs-7 by miR-29 Repression Mediates Vascular Smooth Muscle Calcification | Zendy

Yaoyao Du | Zendy; Cheng Gao | Zendy; Ziyi Liu | Zendy; Li Wang | Zendy; Bo Liu | Zendy; Fan He | Zendy; Tao Zhang | Zendy; Yue Wang | Zendy; XiuJie Wang | Zendy; MingJiang Xu | Zendy; GuanZheng Luo | Zendy; Yi Zhu | Zendy; Qingbo Xu | Zendy; Xian Wang | Zendy; Wei Kong | Zendy

Open Access

Upregulation of a Disintegrin and Metalloproteinase With Thrombospondin Motifs-7 by miR-29 Repression Mediates Vascular Smooth Muscle Calcification

Author(s) -

Yaoyao Du,

Cheng Gao,

Ziyi Liu,

Li Wang,

Bo Liu,

Fan He,

Tao Zhang,

Yue Wang,

XiuJie Wang,

MingJiang Xu,

GuanZheng Luo,

Yi Zhu,

Qingbo Xu,

Xian Wang,

Wei Kong

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300206

Subject(s) - downregulation and upregulation , adamts , calcification , vascular smooth muscle , thrombospondin , metalloproteinase , gene silencing , cartilage oligomeric matrix protein , microbiology and biotechnology , psychological repression , chemistry , matrix metalloproteinase , biology , medicine , endocrinology , pathology , biochemistry , gene expression , alternative medicine , smooth muscle , gene , osteoarthritis

Vascular calcification significantly increases cardiovascular morbidity and mortality. We recently reported that the deficiency of cartilage oligomeric matrix protein (COMP) leads to vascular mineralization. We characterized the COMP-degrading metalloproteinase, a disintegrin and metalloproteinase with thrombospondin motifs-7 (ADAMTS-7). Here, we tested whether ADAMTS-7 facilitates vascular calcification.

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