Antioxidant Enzymes Reduce DNA Damage and Early Activation of Valvular Interstitial Cells in Aortic Valve Sclerosis | Zendy

Emanuela Branchetti | Zendy; Rachana Sainger | Zendy; Paolo Poggio | Zendy; Juan B. Grau | Zendy; Jeffrey Patterson-Fortin | Zendy; Joseph E. Bavaria | Zendy; Michael Chorny | Zendy; Eric Lai | Zendy; Robert C. Gorman | Zendy; Robert J. Levy | Zendy; Giovanni Ferrari | Zendy

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Antioxidant Enzymes Reduce DNA Damage and Early Activation of Valvular Interstitial Cells in Aortic Valve Sclerosis

Author(s) -

Emanuela Branchetti,

Rachana Sainger,

Paolo Poggio,

Juan B. Grau,

Jeffrey Patterson-Fortin,

Joseph E. Bavaria,

Michael Chorny,

Eric Lai,

Robert C. Gorman,

Robert J. Levy,

Giovanni Ferrari

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300177

Subject(s) - aortic valve , antioxidant , enzyme , dna damage , cardiology , medicine , pathology , chemistry , dna , biochemistry

Accumulation of reactive oxygen species (ROS) and remodeling of the microstructure of the cusp characterize aortic valve sclerosis, the early phase of calcific aortic valve disease. These events are associated with activation of valvular interstitial cells (VICs) toward an osteogenic-like phenotype. Because ROS cause DNA damage and transcriptional activation we investigated the relationship between ROS, DNA damage response, and transdifferentiation of VICs.

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