A Systems Biology Framework Identifies Molecular Underpinnings of Coronary Heart Disease | Zendy

Tianxiao Huan | Zendy; Bin Zhang | Zendy; Zhi Wang | Zendy; Roby Joehanes | Zendy; Jun Zhu | Zendy; Andrew D. Johnson | Zendy; Saixia Ying | Zendy; Peter J. Munson | Zendy; Nalini Raghavachari | Zendy; Richard Wang | Zendy; Poching Liu | Zendy; Paul Courchesne | Zendy; ShihJen Hwang | Zendy; Themistocles L. Assimes | Zendy; Ruth McPherson | Zendy; Nilesh J. Samani | Zendy; Heribert Schunkert | Zendy; Qingying Meng | Zendy; Christine Suver | Zendy; Christopher J. O’Donnell | Zendy; Jonathan M.J. Derry | Zendy; Xia Yang | Zendy; Daniel Levy | Zendy

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A Systems Biology Framework Identifies Molecular Underpinnings of Coronary Heart Disease

Author(s) -

Tianxiao Huan,

Bin Zhang,

Zhi Wang,

Roby Joehanes,

Jun Zhu,

Andrew D. Johnson,

Saixia Ying,

Peter J. Munson,

Nalini Raghavachari,

Richard Wang,

Poching Liu,

Paul Courchesne,

ShihJen Hwang,

Themistocles L. Assimes,

Ruth McPherson,

Nilesh J. Samani,

Heribert Schunkert,

Qingying Meng,

Christine Suver,

Christopher J. O’Donnell,

Jonathan M.J. Derry,

Xia Yang,

Daniel Levy

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300112

Subject(s) - biology , gene , gene regulatory network , single nucleotide polymorphism , genetics , disease , computational biology , coronary heart disease , gene expression , genome wide association study , genetic association , bioinformatics , medicine , genotype

Genetic approaches have identified numerous loci associated with coronary heart disease (CHD). The molecular mechanisms underlying CHD gene-disease associations, however, remain unclear. We hypothesized that genetic variants with both strong and subtle effects drive gene subnetworks that in turn affect CHD.

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