Atorvastatin Delays Murine Platelet Activation In Vivo Even in the Absence of Endothelial NO Synthase | Zendy

Ran Ni | Zendy; Tal Peleg | Zendy; Peter L. Gross | Zendy

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Atorvastatin Delays Murine Platelet Activation In Vivo Even in the Absence of Endothelial NO Synthase

Author(s) -

Ran Ni,

Tal Peleg,

Peter L. Gross

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300090

Subject(s) - enos , atorvastatin , platelet activation , thrombin , in vivo , chemistry , platelet , agonist , endothelial activation , pharmacology , medicine , endocrinology , receptor , endothelium , biology , nitric oxide synthase , nitric oxide , microbiology and biotechnology

Statins decrease mortality in patients with vascular disorders, and evidence for the pleiotropic effects of statins is accumulating. Statins enhance endothelial NO synthase (eNOS) expression, thereby attenuating platelet activation and thrombus formation. Our goal was to determine whether statins have eNOS-independent effects on platelet activation.

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