p62 Binding to Protein Kinase C ζ Regulates Tumor Necrosis Factor α–Induced Apoptotic Pathway in Endothelial Cells | Zendy

Geun-Young Kim | Zendy; Patrizia Nigro | Zendy; Keigi Fujiwara | Zendy; Junichi Abe | Zendy; Bradford C. Berk | Zendy

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p62 Binding to Protein Kinase C ζ Regulates Tumor Necrosis Factor α–Induced Apoptotic Pathway in Endothelial Cells

Author(s) -

Geun-Young Kim,

Patrizia Nigro,

Keigi Fujiwara,

Junichi Abe,

Bradford C. Berk

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300054

Subject(s) - apoptosis , microbiology and biotechnology , tumor necrosis factor alpha , vascular endothelial growth inhibitor , ask1 , cancer research , kinase , chemistry , protein kinase a , vascular endothelial growth factor a , biology , mitogen activated protein kinase kinase , vascular endothelial growth factor , immunology , biochemistry , vegf receptors

Protein kinase C (PKC) ζ is a key pathological mediator of endothelial cell apoptosis. p62 is a scaffold protein that regulates several cell signaling pathways by binding to target proteins. Because PKCζ and p62 contain Phox/Bem1p (PB1) modules that mediate protein-protein interactions, we hypothesized that an interaction between p62 and PKCζ is required for tumor necrosis factor α-induced PKCζ signaling in endothelial cells.

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