Hepatocyte Growth Factor Inhibits Lipopolysaccharide-Induced Oxidative Stress via Epithelial Growth Factor Receptor Degradation | Zendy

Kazutaka Shimizu | Zendy; Yoshiaki Taniyama | Zendy; Fumihiro Sanada | Zendy; Junya Azuma | Zendy; Masaaki Iwabayashi | Zendy; Kazuma Iekushi | Zendy; Hiromi Rakugi | Zendy; Ryuichi Morishita | Zendy

Open Access

Hepatocyte Growth Factor Inhibits Lipopolysaccharide-Induced Oxidative Stress via Epithelial Growth Factor Receptor Degradation

Author(s) -

Kazutaka Shimizu,

Yoshiaki Taniyama,

Fumihiro Sanada,

Junya Azuma,

Masaaki Iwabayashi,

Kazuma Iekushi,

Hiromi Rakugi,

Ryuichi Morishita

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300041

Subject(s) - oxidative stress , hepatocyte , lipopolysaccharide , degradation (telecommunications) , microbiology and biotechnology , hepatocyte growth factor receptor , hepatocyte growth factor , chemistry , growth factor , receptor , endocrinology , medicine , biology , biochemistry , in vitro , c met , telecommunications , computer science

Lipopolysaccharide (LPS) triggers sepsis and systemic inflammatory response syndrome, which results in multiple organ failure. Our recent reports demonstrated that hepatocyte growth factor (HGF) attenuated angiotensin II-induced oxidative stress via epithelial growth factor receptor (EGFR) degradation in vascular smooth muscle cells. Here, we examined whether HGF can protect against systemic inflammatory response syndrome induced by LPS and investigated the mechanism.

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