Thrombospondin-1 Regulates Blood Flow via CD47 Receptor–Mediated Activation of NADPH Oxidase 1 | Zendy

Gábor Csányi | Zendy; Mingyi Yao | Zendy; Andrés Rodríguez | Zendy; Imad Al Ghouleh | Zendy; Maryam SharifiSanjani | Zendy; Giovanna Frazziano | Zendy; XiaoJun Huang | Zendy; Eric E. Kelley | Zendy; Jeffrey S. Isenberg | Zendy; Patrick J. Pagano | Zendy

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Thrombospondin-1 Regulates Blood Flow via CD47 Receptor–Mediated Activation of NADPH Oxidase 1

Author(s) -

Gábor Csányi,

Mingyi Yao,

Andrés Rodríguez,

Imad Al Ghouleh,

Maryam SharifiSanjani,

Giovanna Frazziano,

XiaoJun Huang,

Eric E. Kelley,

Jeffrey S. Isenberg,

Patrick J. Pagano

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.300031

Subject(s) - nadph oxidase , cd47 , thrombospondin 1 , thrombospondin , microbiology and biotechnology , receptor , chemistry , medicine , immunology , biology , enzyme , biochemistry , cancer research , angiogenesis , reactive oxygen species , metalloproteinase

Although the matricellular protein thrombospondin-1 (TSP1) is highly expressed in the vessel wall in response to injury, its pathophysiological role in the development of vascular disease is poorly understood. This study was designed to test the hypothesis that TSP1 stimulates reactive oxygen species production in vascular smooth muscle cells and induces vascular dysfunction by promoting oxidative stress.

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