Skin Autofluorescence as a Measure of Advanced Glycation End Products Deposition Is Elevated in Peripheral Artery Disease
Author(s) -
Lisanne C. de Vos,
Marjon J. Noordzij,
Douwe J. Mulder,
Andries J. Smit,
Helen L. Lutgers,
Robin P. F. Dullaart,
Pieter W. Kamphuisen,
Clark J. Zeebregts,
Joop D. Lefrandt
Publication year - 2012
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.112.300016
Subject(s) - medicine , diabetes mellitus , comorbidity , coronary artery disease , odds ratio , kidney disease , cardiology , confounding , vascular disease , confidence interval , abdominal aortic aneurysm , surgery , aneurysm , endocrinology
Evidence for an important role of advanced glycation end products (AGEs) in the development of atherosclerosis and cardiovascular disease beyond diabetes mellitus and renal disease is growing. Skin autofluorescence (SAF) is a validated noninvasive measure of tissue AGEs. We hypothesized that SAF is elevated in peripheral artery disease (PAD).
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