Open AccessAdverse Alterations in Mitochondrial Function Contribute to Type 2 Diabetes Mellitus–Related Endothelial Dysfunction in Humans
Author(s) -
Tinoy Kizhakekuttu,
Jingli Wang,
Kodlipet Dharmashankar,
Rong Ying,
David D. Gutterman,
Joseph A. Vita,
Michael E. Widlansky
Publication year - 2012
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.112.256024
Subject(s) - superoxide , mitochondrion , medicine , endocrinology , endothelial dysfunction , mitochondrial ros , biology , chemistry , biochemistry , enzyme
Mitochondrial dysfunction plays a key pathophysiological role in type 2 diabetes mellitus (T2DM). Data delineating relationships between mitochondrial and endothelial dysfunction in humans with T2DM are lacking.
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