Modulation of the Cochaperone AHA1 Regulates Heat-Shock Protein 90 and Endothelial NO Synthase Activation by Vascular Endothelial Growth Factor | Zendy

Fanny Desjardins | Zendy; Chantal Delisle | Zendy; JeanPhilippe Gratton | Zendy

Open Access

Modulation of the Cochaperone AHA1 Regulates Heat-Shock Protein 90 and Endothelial NO Synthase Activation by Vascular Endothelial Growth Factor

Author(s) -

Fanny Desjardins,

Chantal Delisle,

JeanPhilippe Gratton

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.256008

Subject(s) - heat shock protein , microbiology and biotechnology , shock (circulatory) , modulation (music) , chemistry , biology , medicine , biochemistry , physics , gene , acoustics

Vascular endothelial growth factor (VEGF) signaling to endothelial NO synthase (eNOS) plays a central role in angiogenesis. In endothelial cells (ECs), heat-shock protein 90 (Hsp90) is also a regulator of eNOS activity. Our study is designed to determine whether modulation of the activator of Hsp90 ATPase 1 (AHA1) regulates the function of Hsp90 in ECs.

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