Dynamin-Related Protein-1 Controls Fusion Pore Dynamics During Platelet Granule Exocytosis | Zendy

Secil Koseoglu | Zendy; James R. Dilks | Zendy; Christian Peters | Zendy; Jennifer L. Fitch-Tewfik | Zendy; Nathalie A. Fadel | Zendy; Reema Jasuja | Zendy; Joseph E. Italiano | Zendy; Christy L. Haynes | Zendy; Robert Flaumenhaft | Zendy

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Dynamin-Related Protein-1 Controls Fusion Pore Dynamics During Platelet Granule Exocytosis

Author(s) -

Secil Koseoglu,

James R. Dilks,

Christian Peters,

Jennifer L. Fitch-Tewfik,

Nathalie A. Fadel,

Reema Jasuja,

Joseph E. Italiano,

Christy L. Haynes,

Robert Flaumenhaft

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.255737

Subject(s) - exocytosis , granule (geology) , platelet , microbiology and biotechnology , dnm1l , lipid bilayer fusion , biophysics , chemistry , platelet activation , dense granule , biology , biochemistry , membrane , immunology , paleontology , mitochondrial fission , mitochondrion

Platelet granule exocytosis serves a central role in hemostasis and thrombosis. Recently, single-cell amperometry has shown that platelet membrane fusion during granule exocytosis results in the formation of a fusion pore that subsequently expands to enable the extrusion of granule contents. However, the molecular mechanisms that control platelet fusion pore expansion and collapse are not known.

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