Differences in Health Status Affect Susceptibility and Mapping of Genetic Loci for Atherosclerosis (Fatty Streak) in Inbred Mice | Zendy

Ujala Srivastava | Zendy; Beverly Paigen | Zendy; Ron Korstanje | Zendy

Open Access

Differences in Health Status Affect Susceptibility and Mapping of Genetic Loci for Atherosclerosis (Fatty Streak) in Inbred Mice

Author(s) -

Ujala Srivastava,

Beverly Paigen,

Ron Korstanje

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.255703

Subject(s) - fatty streak , biology , quantitative trait locus , genetics , inbred strain , single nucleotide polymorphism , genetic predisposition , genotype , genome wide association study , gene , cholesterol , endocrinology

We observed differences in atherosclerosis susceptibility in mouse inbred strains over the years as the health status of our animal rooms increased. Therefore, we investigated the effect of animal room health status on atherosclerosis susceptibility in different strains. As these data can also be used for genome-wide association mapping, we performed a mapping study and compared our results with previously found quantitative trait loci for atherosclerosis in mouse and humans.

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