Elevated Protein Kinase C-δ Contributes to Aneurysm Pathogenesis Through Stimulation of Apoptosis and Inflammatory Signaling | Zendy

Stephanie Morgan | Zendy; Dai Yamanouchi | Zendy; Calvin Harberg | Zendy; Qiwei Wang | Zendy; Melissa R. Keller | Zendy; Yi Si | Zendy; William J. Burlingham | Zendy; Stephen Seedial | Zendy; Justin Lengfeld | Zendy; Bo Liu | Zendy

Open Access

Elevated Protein Kinase C-δ Contributes to Aneurysm Pathogenesis Through Stimulation of Apoptosis and Inflammatory Signaling

Author(s) -

Stephanie Morgan,

Dai Yamanouchi,

Calvin Harberg,

Qiwei Wang,

Melissa R. Keller,

Yi Si,

William J. Burlingham,

Stephen Seedial,

Justin Lengfeld,

Bo Liu

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.255661

Subject(s) - proinflammatory cytokine , protein kinase c , apoptosis , inflammation , monocyte , cancer research , signal transduction , microbiology and biotechnology , biology , medicine , immunology , biochemistry

Apoptosis of smooth muscle cells (SMCs) is a prominent pathological characteristic of abdominal aortic aneurysm (AAA). We have previously shown that SMC apoptosis stimulates proinflammatory signaling in a mouse model of AAA. Here, we test whether protein kinase C-δ (PKCδ), an apoptotic mediator, participates in the pathogenesis of AAA by regulating apoptosis and proinflammatory signals.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research