Open AccessLipoprotein(a) and Risk of Coronary, Cerebrovascular, and Peripheral Artery Disease
Author(s) -
Deepti Gurdasani,
Barbara Sjouke,
Sotirios Tsimikas,
G. Kees Hovingh,
Robert Luben,
Nicholas W.J. Wainwright,
Cristina Pomilla,
Nicholas J. Wareham,
KayTee Khaw,
S. Matthijs Boekholdt,
Manjinder S. Sandhu
Publication year - 2012
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.112.255521
Subject(s) - medicine , lipoprotein(a) , hazard ratio , stroke (engine) , coronary artery disease , prospective cohort study , risk factor , cardiology , lipoprotein , proportional hazards model , vascular disease , cholesterol , confidence interval , mechanical engineering , engineering
Although the association between circulating levels of lipoprotein(a) [Lp(a)] and risk of coronary artery disease (CAD) and stroke is well established, its role in risk of peripheral arterial disease (PAD) remains unclear. Here, we examine the association between Lp(a) levels and PAD in a large prospective cohort. To contextualize these findings, we also examined the association between Lp(a) levels and risk of stroke and CAD and studied the role of low-density lipoprotein as an effect modifier of Lp(a)-associated cardiovascular risk.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom