Platelets Derived From the Bone Marrow of Diabetic Animals Show Dysregulated Endoplasmic Reticulum Stress Proteins That Contribute to Increased Thrombosis | Zendy

Rodrigo Hernández Vera | Zendy; Gemma Vilahur | Zendy; Raquel FerrerLorente | Zendy; Esther Peña | Zendy; Lina Badimón | Zendy

Open Access

Platelets Derived From the Bone Marrow of Diabetic Animals Show Dysregulated Endoplasmic Reticulum Stress Proteins That Contribute to Increased Thrombosis

Author(s) -

Rodrigo Hernández Vera,

Gemma Vilahur,

Raquel FerrerLorente,

Esther Peña,

Lina Badimón

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.255281

Subject(s) - medicine , platelet , diabetes mellitus , endocrinology , thrombosis , platelet activation , endoplasmic reticulum , thrombogenicity , bone marrow , biology , biochemistry

Patients with diabetes mellitus have an increased risk of suffering atherothrombotic syndromes and are prone to clustering cardiovascular risk factors. However, despite their dysregulated glucose metabolism, intensive glycemic control has proven insufficient to reduce thrombotic complications. Therefore, we aimed to elucidate the determinants of thrombosis in a model of type 2 diabetes mellitus with cardiovascular risk factors clustering.

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