Mitochondrial Motility and Vascular Smooth Muscle Proliferation | Zendy

Susan Chalmers | Zendy; Christopher D. Saunter | Zendy; Calum Wilson | Zendy; Paul Coats | Zendy; John M. Girkin | Zendy; John G. McCarron | Zendy

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Mitochondrial Motility and Vascular Smooth Muscle Proliferation

Author(s) -

Susan Chalmers,

Christopher D. Saunter,

Calum Wilson,

Paul Coats,

John M. Girkin,

John G. McCarron

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.255174

Subject(s) - mitochondrion , microbiology and biotechnology , motility , organelle , vascular smooth muscle , biology , myocyte , cytoplasm , cell , smooth muscle , biochemistry , endocrinology

Mitochondria are widely described as being highly dynamic and adaptable organelles, and their movement is thought to be vital for cell function. Yet, in various native cells, including those of heart and smooth muscle, mitochondria are stationary and rigidly structured. The significance of the differences in mitochondrial behavior to the physiological function of cells is unclear and was studied in single myocytes and intact resistance-sized cerebral arteries. We hypothesized that mitochondrial dynamics is controlled by the proliferative status of the cells.

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