Myeloid-Specific IκB Kinase β Deficiency Decreases Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice | Zendy

Sehyung Park | Zendy; Yipeng Sui | Zendy; Florence Gizard | Zendy; Jinxian Xu | Zendy; Jennifer Rios-Pilier | Zendy; Robert N. Helsley | Zendy; SeongSu Han | Zendy; Changcheng Zhou | Zendy

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Myeloid-Specific IκB Kinase β Deficiency Decreases Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

Author(s) -

Sehyung Park,

Yipeng Sui,

Florence Gizard,

Jinxian Xu,

Jennifer Rios-Pilier,

Robert N. Helsley,

SeongSu Han,

Changcheng Zhou

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.254573

Subject(s) - iκb kinase , inflammation , macrophage , foam cell , myeloid , lipoprotein , immunology , proinflammatory cytokine , medicine , ldl receptor , cancer research , biology , nf κb , cholesterol , biochemistry , in vitro

Inflammatory responses are the driving force of atherosclerosis development. IκB kinase β (IKKβ), a central coordinator in inflammation through regulation of nuclear factor-κB, has been implicated in the pathogenesis of atherosclerosis. Macrophages play an essential role in the initiation and progression of atherosclerosis, yet the role of macrophage IKKβ in atherosclerosis remains elusive and controversial. This study aims to investigate the impact of IKKβ expression on macrophage functions and to assess the effect of myeloid-specific IKKβ deletion on atherosclerosis development.

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