Caveolin-1 Plays a Critical Role in the Differentiation of Monocytes into Macrophages | Zendy

Yi Fu | Zendy; XiaoLei Moore | Zendy; Man K.S. Lee | Zendy; Manuel A. FernándezRojo | Zendy; MarieOdile Parat | Zendy; Robert G. Parton | Zendy; Peter J. Meikle | Zendy; Dmitri Sviridov | Zendy; Jaye ChinDusting | Zendy

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Caveolin-1 Plays a Critical Role in the Differentiation of Monocytes into Macrophages

Author(s) -

Yi Fu,

XiaoLei Moore,

Man K.S. Lee,

Manuel A. FernándezRojo,

MarieOdile Parat,

Robert G. Parton,

Peter J. Meikle,

Dmitri Sviridov,

Jaye ChinDusting

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.254151

Subject(s) - monocyte , microbiology and biotechnology , gene knockdown , caveolae , biology , cellular differentiation , caveolin 1 , kinase , small interfering rna , chemistry , transfection , signal transduction , biochemistry , immunology , gene

Monocyte to macrophage differentiation is an essential step in atherogenesis. The structure protein of caveolae, caveolin-1, is increased in primary monocytes after its adhesion to endothelium. We explore the hypothesis that caveolin-1 plays a role in monocyte differentiation to macrophages.

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