Simultaneous Exposure of Sites in von Willebrand Factor for Glycoprotein Ib Binding and ADAMTS13 Cleavage | Zendy

Junmei Chen | Zendy; Minhua Ling | Zendy; Xiaoyun Fu | Zendy; José A. López | Zendy; Dominic W. Chung | Zendy

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Simultaneous Exposure of Sites in von Willebrand Factor for Glycoprotein Ib Binding and ADAMTS13 Cleavage

Author(s) -

Junmei Chen,

Minhua Ling,

Xiaoyun Fu,

José A. López,

Dominic W. Chung

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.254144

Subject(s) - adamts13 , von willebrand factor , ristocetin , chemistry , platelet membrane glycoprotein , glycoprotein ib , proteolysis , cleavage (geology) , von willebrand disease , glycoprotein , platelet , binding site , recombinant dna , biochemistry , biology , enzyme , immunology , gene , paleontology , fracture (geology)

Platelet-bound von Willebrand factor (VWF) was recently demonstrated to be a better substrate for ADAMTS13, suggesting that 1 conformational change exposes both the glycoprotein Ibα binding site in the A1 domain and the ADAMTS13 cleavage site in the A2 domain. Because ristocetin induces VWF to bind glycoprotein Ibα in the absence of shear stress, we evaluated whether it could also enhance ADAMTS13 proteolysis of VWF.

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