P300/CBP Associated Factor Regulates Nitroglycerin-Dependent Arterial Relaxation by N ε -Lysine Acetylation of Contractile Proteins | Zendy

Claudia Colussi | Zendy; Alessandro Scopece | Zendy; Serena Vitale | Zendy; Francesco Spallotta | Zendy; Stefania Mattiussi | Zendy; Jessica Rosati | Zendy; Barbara Illi | Zendy; Antonello Mai | Zendy; Sabrina Castellano | Zendy; Gianluca Sbardella | Zendy; Antonella Farsetti | Zendy; Maurizio C. Capogrossi | Zendy; Carlo Gaetano | Zendy

Open Access

P300/CBP Associated Factor Regulates Nitroglycerin-Dependent Arterial Relaxation by N ^ε -Lysine Acetylation of Contractile Proteins

Author(s) -

Claudia Colussi,

Alessandro Scopece,

Serena Vitale,

Francesco Spallotta,

Stefania Mattiussi,

Jessica Rosati,

Barbara Illi,

Antonello Mai,

Sabrina Castellano,

Gianluca Sbardella,

Antonella Farsetti,

Maurizio C. Capogrossi,

Carlo Gaetano

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.254011

Subject(s) - creb , trichostatin a , acetylation , histone , histone deacetylase , lysine , histone h3 , histone deacetylase inhibitor , histone h4 , myosin light chain kinase , pharmacology , chemistry , biology , biochemistry , transcription factor , myosin , amino acid , gene

To address the role of epigenetic enzymes in the process of arterial vasorelaxation and nitrate tolerance, in vitro and in vivo experiments were performed in the presence or absence of glyceryl trinitrate (GTN) or histone deacetylases/histone acetylases modulators.

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