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To address the role of epigenetic enzymes in the process of arterial vasorelaxation and nitrate tolerance, in vitro and in vivo experiments were performed in the presence or absence of glyceryl trinitrate (GTN) or histone deacetylases/histone acetylases modulators.

P300/CBP Associated Factor Regulates Nitroglycerin-Dependent Arterial Relaxation by N ε -Lysine Acetylation of Contractile Proteins

P300/CBP Associated Factor Regulates Nitroglycerin-Dependent Arterial Relaxation by N ^ε -Lysine Acetylation of Contractile Proteins