Antithrombotic Properties of Water-Soluble Carbon Monoxide-Releasing Molecules | Zendy

Karol Kramkowski | Zendy; Agnieszka Leszczyńska | Zendy; Andrzej Mogielnicki | Zendy; Stefan Chłopicki | Zendy; Andrzej Fedorowicz | Zendy; Elżbieta Grochal | Zendy; Brian E. Mann | Zendy; Tomasz Brzóska | Zendy; Tetsumei Urano | Zendy; Roberto Motterlini | Zendy; Włodzimierz Buczko | Zendy

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Antithrombotic Properties of Water-Soluble Carbon Monoxide-Releasing Molecules

Author(s) -

Karol Kramkowski,

Agnieszka Leszczyńska,

Andrzej Mogielnicki,

Stefan Chłopicki,

Andrzej Fedorowicz,

Elżbieta Grochal,

Brian E. Mann,

Tomasz Brzóska,

Tetsumei Urano,

Roberto Motterlini,

Włodzimierz Buczko

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.253989

Subject(s) - carbon monoxide , antithrombotic , chemistry , molecule , chemical engineering , medicine , organic chemistry , cardiology , catalysis , engineering

We compared the antithrombotic effects in vivo of 2 chemically different carbon monoxide-releasing molecules (CORM-A1 and CORM-3) on arterial and venous thrombus formation and on hemostatic parameters such as platelet activation, coagulation, and fibrinolysis. The hypotensive response to CORMs and their effects on whole blood gas analysis and blood cell count were also examined.

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