Clinical and Genetic Association of Serum Paraoxonase and Arylesterase Activities With Cardiovascular Risk | Zendy

W.H. Wilson Tang | Zendy; Jaana Hartiala | Zendy; Yiying Fan | Zendy; Yuping Wu | Zendy; Alexandre F.R. Stewart | Zendy; Jeanette Erdmann | Zendy; Sekar Kathiresan | Zendy; Robert Roberts | Zendy; Ruth McPherson | Zendy; Hooman Allayee | Zendy; Stanley L. Hazen | Zendy

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Clinical and Genetic Association of Serum Paraoxonase and Arylesterase Activities With Cardiovascular Risk

Author(s) -

W.H. Wilson Tang,

Jaana Hartiala,

Yiying Fan,

Yuping Wu,

Alexandre F.R. Stewart,

Jeanette Erdmann,

Sekar Kathiresan,

Robert Roberts,

Ruth McPherson,

Hooman Allayee,

Stanley L. Hazen

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.253930

Subject(s) - arylesterase , paraoxonase , mace , medicine , myocardial infarction , pon1 , cardiology , quartile , aryldialkylphosphatase , endocrinology , oxidative stress , genotype , biology , genetics , percutaneous coronary intervention , confidence interval , gene

Diminished serum paraoxonase and arylesterase activities (measures of paraoxonase-1 [PON-1] function) in humans have been linked to heightened systemic oxidative stress and atherosclerosis risk. The clinical prognostic use of measuring distinct PON-1 activities has not been established, and the genetic determinants of PON-1 activities are not known.

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