Combination Therapy With VELCADE and Tissue Plasminogen Activator Is Neuroprotective in Aged Rats After Stroke and Targets MicroRNA-146a and the Toll-Like Receptor Signaling Pathway | Zendy

Li Zhang | Zendy; Michael Chopp | Zendy; Xianshuang Liu | Zendy; Hua Teng | Zendy; Tao Tang | Zendy; Haifa Kassis | Zendy; Zheng Gang Zhang | Zendy

Open Access

Combination Therapy With VELCADE and Tissue Plasminogen Activator Is Neuroprotective in Aged Rats After Stroke and Targets MicroRNA-146a and the Toll-Like Receptor Signaling Pathway

Author(s) -

Li Zhang,

Michael Chopp,

Xianshuang Liu,

Hua Teng,

Tao Tang,

Haifa Kassis,

Zheng Gang Zhang

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.252619

Subject(s) - neuroprotection , stroke (engine) , medicine , microrna , tissue plasminogen activator , signal transduction , receptor , pharmacology , cancer research , immunology , bioinformatics , biology , microbiology and biotechnology , gene , biochemistry , mechanical engineering , engineering

Activation of the toll-like receptor (TLR) signaling pathway exacerbates ischemic brain damage. The present study tested the hypothesis that combination treatment with VELCADE and tissue plasminogen activator (tPA) modulates the TLR signaling pathway on cerebral vasculature, which leads to neuroprotection in aged rats after stroke.

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