Fibroblast Growth Factor-2 Is Required for Vasa Vasorum Plexus Stability in Hypercholesterolemic Mice | Zendy

Jessica Mollmark | Zendy; Andrew J.-H. Park | Zendy; Justin Kim | Zendy; Thomas Z. Wang | Zendy; Sarah Katzenell | Zendy; Samantha Shipman | Zendy; Lyubomir Zagorchev | Zendy; Michael Simons | Zendy; Mary Jo MulliganKehoe | Zendy

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Fibroblast Growth Factor-2 Is Required for Vasa Vasorum Plexus Stability in Hypercholesterolemic Mice

Author(s) -

Jessica Mollmark,

Andrew J.-H. Park,

Justin Kim,

Thomas Z. Wang,

Sarah Katzenell,

Samantha Shipman,

Lyubomir Zagorchev,

Michael Simons,

Mary Jo MulliganKehoe

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.252544

Subject(s) - vasa vasorum , fibroblast growth factor , plasmin , adventitia , endocrinology , plasminogen activator , medicine , receptor , chemistry , biology , microbiology and biotechnology , anatomy , biochemistry , enzyme

Vasa vasorum are angiogenic in advanced stages of human atherosclerosis and hypercholesterolemic mouse models. Fibroblast growth factor-2 (FGF-2) is the predominant angiogenic growth factor in the adventitia and plaque of hypercholesterolemic low-density lipoprotein receptor-deficient/apolipoprotein B(100/100) mice (DKO). FGF-2 seems to play a role in the formation of a distinct vasa vasorum network. This study examined the vasa vasorum structure and its relationship to FGF-2.

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