A Disintegrin and Metalloproteinase 15 Contributes to Atherosclerosis by Mediating Endothelial Barrier Dysfunction via Src Family Kinase Activity | Zendy

Chongxiu Sun | Zendy; Mack H. Wu | Zendy; Eugene S. Lee | Zendy; Sarah Y. Yuan | Zendy

Open Access

A Disintegrin and Metalloproteinase 15 Contributes to Atherosclerosis by Mediating Endothelial Barrier Dysfunction via Src Family Kinase Activity

Author(s) -

Chongxiu Sun,

Mack H. Wu,

Eugene S. Lee,

Sarah Y. Yuan

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.252205

Subject(s) - disintegrin , metalloproteinase , proto oncogene tyrosine protein kinase src , src family kinase , endothelial dysfunction , kinase , microbiology and biotechnology , matrix metalloproteinase , cancer research , medicine , biology

Endothelium dysfunction is an initiating factor in atherosclerosis. A disintegrin and metalloproteinase 15 (ADAM 15) is a multidomain metalloprotease recently identified as a regulator of endothelial permeability. However, whether and how ADAM15 contributes to atherosclerosis remains unknown.

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