Genotype-Dependent Impairment of Hemoglobin Clearance Increases Oxidative and Inflammatory Response in Human Diabetic Atherosclerosis | Zendy

Meerarani Purushothaman | Zendy; Prakash Krishnan | Zendy; KRaman Purushothaman | Zendy; Usman Baber | Zendy; Arthur Tarricone | Zendy; Juan Suárez Pérez | Zendy; Jose Wiley | Zendy; Annapoorna Kini | Zendy; Samin K. Sharma | Zendy; Valentı́n Fuster | Zendy; Pedro R. Moreno | Zendy

Open Access

Genotype-Dependent Impairment of Hemoglobin Clearance Increases Oxidative and Inflammatory Response in Human Diabetic Atherosclerosis

Author(s) -

Meerarani Purushothaman,

Prakash Krishnan,

KRaman Purushothaman,

Usman Baber,

Arthur Tarricone,

Juan Suárez Pérez,

Jose Wiley,

Annapoorna Kini,

Samin K. Sharma,

Valentı́n Fuster,

Pedro R. Moreno

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.252122

Subject(s) - cd163 , haptoglobin , myeloperoxidase , hemoglobin , heme oxygenase , atheroma , medicine , inflammation , endocrinology , heme , chemistry , immunology , macrophage , biochemistry , in vitro , enzyme

Haptoglobin (Hp) protein is responsible for hemoglobin clearance after intra-plaque hemorrhage. Hp gene exists as Hp-1 and Hp-2 alleles and the phenotypes show important molecular heterogeneity. We tested the hypothesis that hemoglobin clearance may be deficient in diabetic atheroma from patients with Hp2-2, triggering increased oxidative, inflammatory, and angiogenic patterns compared with controls.

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