Angiopoietin-1 and Vascular Endothelial Growth Factor Regulation of Leukocyte Adhesion to Endothelial Cells | Zendy

Hodan Ismail | Zendy; Mahroo Mofarrahi | Zendy; Raquel Echavarría | Zendy; Sharon Harel | Zendy; Eric Verdin | Zendy; Hyung W. Lim | Zendy; ZhengGen Jin | Zendy; Jianxin Sun | Zendy; Huiyan Zeng | Zendy; Sabah N. A. Hussain | Zendy

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Angiopoietin-1 and Vascular Endothelial Growth Factor Regulation of Leukocyte Adhesion to Endothelial Cells

Author(s) -

Hodan Ismail,

Mahroo Mofarrahi,

Raquel Echavarría,

Sharon Harel,

Eric Verdin,

Hyung W. Lim,

ZhengGen Jin,

Jianxin Sun,

Huiyan Zeng,

Sabah N. A. Hussain

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.251546

Subject(s) - nerve growth factor ib , microbiology and biotechnology , vascular endothelial growth factor , cell adhesion molecule , biology , small interfering rna , vascular endothelial growth factor c , signal transduction , cell adhesion , vascular endothelial growth factor a , chemistry , cancer research , transcription factor , nuclear receptor , cell , cell culture , biochemistry , transfection , vegf receptors , gene , genetics

Vascular endothelial growth factor (VEGF) promotes leukocyte adhesion to endothelial cells (ECs). Angiopoietin-1 (Ang-1) inhibits this response. Nuclear receptor-77 (Nur77) is a proangiogenic nuclear receptor. In the present study, we assessed the influence of Ang-1 and VEGF on Nur77 expression in ECs, and evaluated its role in Ang-1/VEGF-mediated leukocyte adhesion.

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