Endoluminal Gingival Fibroblast Transfer Reduces the Size of Rabbit Carotid Aneurisms via Elastin Repair | Zendy

Éric Durand | Zendy; Benjamin Fournier | Zendy; Ludovic Couty | Zendy; Mathilde Lemitre | Zendy; Paul Achouh | Zendy; Pierre Julia | Zendy; Ludovic Trinquart | Zendy; Jean Noël Fabiani | Zendy; Sylvie Séguier | Zendy; Bruno Gogly | Zendy; Bernard Coulomb | Zendy; Antoine Lafont | Zendy

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Endoluminal Gingival Fibroblast Transfer Reduces the Size of Rabbit Carotid Aneurisms via Elastin Repair

Author(s) -

Éric Durand,

Benjamin Fournier,

Ludovic Couty,

Mathilde Lemitre,

Paul Achouh,

Pierre Julia,

Ludovic Trinquart,

Jean Noël Fabiani,

Sylvie Séguier,

Bruno Gogly,

Bernard Coulomb,

Antoine Lafont

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.251439

Subject(s) - elastin , matrix metalloproteinase , fibroblast , in vivo , transplantation , chemistry , matrix (chemical analysis) , metalloproteinase , carotid arteries , in vitro , medicine , pathology , biochemistry , biology , microbiology and biotechnology , chromatography

Matrix metalloproteinase-9 is considered to play a pivotal role in aneurismal formation. We showed that gingival fibroblasts (GF) in vitro reduced matrix metalloproteinase-9 activity via increased secretion of tissue inhibitor of metalloproteinase 1. We aimed to evaluate in vivo the efficacy of GF transplantation to reduce aneurism development in a rabbit model.

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