Blocking Toll-Like Receptors 7 and 9 Reduces Postinterventional Remodeling via Reduced Macrophage Activation, Foam Cell Formation, and Migration | Zendy

Jacco C. Karper | Zendy; M.M. Ewing | Zendy; Kim L. L. Habets | Zendy; Margreet R. de Vries | Zendy; Erna A Peters | Zendy; Annemarie M. van OeverenRietdijk | Zendy; Hetty C. de Boer | Zendy; Jaap F. Hamming | Zendy; Johan Kuiper | Zendy; Ekambar R. Kandimalla | Zendy; Nicola La Monica | Zendy; J. Wouter Jukema | Zendy; Paul H.A. Quax | Zendy

Open Access

Blocking Toll-Like Receptors 7 and 9 Reduces Postinterventional Remodeling via Reduced Macrophage Activation, Foam Cell Formation, and Migration

Author(s) -

Jacco C. Karper,

M.M. Ewing,

Kim L. L. Habets,

Margreet R. de Vries,

Erna A Peters,

Annemarie M. van OeverenRietdijk,

Hetty C. de Boer,

Jaap F. Hamming,

Johan Kuiper,

Ekambar R. Kandimalla,

Nicola La Monica,

J. Wouter Jukema,

Paul H.A. Quax

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.249391

Subject(s) - foam cell , chemistry , cd36 , tlr7 , receptor , inflammation , antagonist , medicine , endocrinology , tlr9 , toll like receptor , lipoprotein , cholesterol , innate immune system , biochemistry , gene expression , dna methylation , gene

The role of toll-like receptors (TLRs) in vascular remodeling is well established. However, the involvement of the endosomal TLRs is unknown. Here, we study the effect of combined blocking of TLR7 and TLR9 on postinterventional remodeling and accelerated atherosclerosis.

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