Reactive Oxygen Species Regulate Osteopontin Expression in a Murine Model of Postischemic Neovascularization | Zendy

Alicia N. Lyle | Zendy; Giji Joseph | Zendy; Aaron E. Fan | Zendy; Daiana Weiss | Zendy; Natalia Landázuri | Zendy; W. Robert Taylor | Zendy

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Reactive Oxygen Species Regulate Osteopontin Expression in a Murine Model of Postischemic Neovascularization

Author(s) -

Alicia N. Lyle,

Giji Joseph,

Aaron E. Fan,

Daiana Weiss,

Natalia Landázuri,

W. Robert Taylor

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.248922

Subject(s) - osteopontin , ischemia , neovascularization , angiogenesis , downregulation and upregulation , catalase , chemistry , in vivo , biology , endocrinology , cancer research , oxidative stress , medicine , biochemistry , microbiology and biotechnology , gene

Previous findings from our laboratory demonstrated that neovascularization was impaired in osteopontin (OPN) knockout animals. However, the mechanisms responsible for the regulation of OPN expression in the setting of ischemia remain undefined. Therefore, we sought to determine whether OPN is upregulated in response to ischemia and hypothesized that hydrogen peroxide (H(2)O(2)) is a critical component of the signaling mechanism by which OPN expression is upregulated in response to ischemia in vivo.

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