Synergistic Effect of Thrombin and CD40 Ligand on Endothelial Matrix Metalloproteinase-10 Expression and Microparticle Generation In Vitro and In Vivo | Zendy

Sara Martínez de Lizarrondo | Zendy; Carmen Roncal | Zendy; Olivier Calvayrac | Zendy; Cristina Rodrı́guez | Zendy; Nerea Varo | Zendy; Ana Purroy | Zendy; Leonardo Lorente | Zendy; José Antonio Rodríguez | Zendy; Loïc Doeuvre | Zendy; Sandra HervásStubbs | Zendy; Eduardo AnglésCano | Zendy; José A. Páramo | Zendy; José MartínezGonzález | Zendy; Josune Orbe | Zendy

Open Access

Synergistic Effect of Thrombin and CD40 Ligand on Endothelial Matrix Metalloproteinase-10 Expression and Microparticle Generation In Vitro and In Vivo

Author(s) -

Sara Martínez de Lizarrondo,

Carmen Roncal,

Olivier Calvayrac,

Cristina Rodrı́guez,

Nerea Varo,

Ana Purroy,

Leonardo Lorente,

José Antonio Rodríguez,

Loïc Doeuvre,

Sandra HervásStubbs,

Eduardo AnglésCano,

José A. Páramo,

José MartínezGonzález,

Josune Orbe

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.248773

Subject(s) - thrombin , cd40 , matrix metalloproteinase , endothelial stem cell , inflammation , chemistry , thrombin receptor , microbiology and biotechnology , immunology , medicine , biology , in vitro , biochemistry , platelet , cytotoxic t cell

Thrombin induces CD40 ligand (CD40L) and matrix metalloproteinases (MMPs) under inflammatory/prothrombotic conditions. Thrombin and CD40L could modulate endothelial MMP-10 expression in vitro and in vivo.

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