A Genome-Wide Association Study Identifies KNG1 as a Genetic Determinant of Plasma Factor XI Level and Activated Partial Thromboplastin Time | Zendy

Maria SabaterLleal | Zendy; Ángel Martínez-Pérez | Zendy; Alfonso Buil | Zendy; Lasse Folkersen | Zendy; Juan Carlos Souto | Zendy; Maria Bruzelius | Zendy; Montserrat Borrell | Zendy; Jacob Odeberg | Zendy; Angela Silveira | Zendy; Per Eriksson | Zendy; Laura Almasy | Zendy; Anders Hamsten | Zendy; José Manuel Soria | Zendy

Open Access

A Genome-Wide Association Study Identifies KNG1 as a Genetic Determinant of Plasma Factor XI Level and Activated Partial Thromboplastin Time

Author(s) -

Maria SabaterLleal,

Ángel Martínez-Pérez,

Alfonso Buil,

Lasse Folkersen,

Juan Carlos Souto,

Maria Bruzelius,

Montserrat Borrell,

Jacob Odeberg,

Angela Silveira,

Per Eriksson,

Laura Almasy,

Anders Hamsten,

José Manuel Soria

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.248492

Subject(s) - partial thromboplastin time , genome wide association study , population , single nucleotide polymorphism , medicine , thrombosis , venous thrombosis , genetic association , biology , bioinformatics , genetics , coagulation , immunology , gene , genotype , environmental health

Elevated plasma levels of coagulation factor XI (FXI) are implicated in the pathogenesis of venous thromboembolism and ischemic stroke, and polymorphisms in the F11 gene are associated both with risk of venous thromboembolism and an elevated plasma FXI level.

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