Induction of Angiotensin-Converting Enzyme and Activation of the Renin–Angiotensin System Contribute to 20-Hydroxyeicosatetraenoic Acid–Mediated Endothelial Dysfunction | Zendy

Jennifer Cheng | Zendy; Víctor García | Zendy; Yan Ding | Zendy; ChengChia Wu | Zendy; Krutanjali Thakar | Zendy; John R. Falck | Zendy; Errabelli Ramu | Zendy; Michal L. Schwartzman | Zendy

Open Access

Induction of Angiotensin-Converting Enzyme and Activation of the Renin–Angiotensin System Contribute to 20-Hydroxyeicosatetraenoic Acid–Mediated Endothelial Dysfunction

Author(s) -

Jennifer Cheng,

Víctor García,

Yan Ding,

ChengChia Wu,

Krutanjali Thakar,

John R. Falck,

Errabelli Ramu,

Michal L. Schwartzman

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.248344

Subject(s) - renin–angiotensin system , hydroxyeicosatetraenoic acid , endothelial dysfunction , angiotensin ii , enzyme , endocrinology , angiotensin converting enzyme , medicine , endothelial stem cell , chemistry , biology , biochemistry , arachidonic acid , blood pressure , in vitro

20-hydroxyeicosatetraenoic acid (20-HETE) promotes endothelial dysfunction by uncoupling endothelial NO synthase, stimulating O(2)(-) production, and reducing NO bioavailability. Moreover, 20-HETE-dependent vascular dysfunction and hypertension are associated with upregulation of the renin-angiotensin system This study was undertaken to examine the contribution of renin-angiotensin system to 20-HETE actions in the vascular endothelium.

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