Apolipoprotein E4 Domain Interaction Accelerates Diet-Induced Atherosclerosis in Hypomorphic Arg-61 Apoe Mice | Zendy

Delphine Eberlé | Zendy; Roy Kim | Zendy; Fu Sang Luk | Zendy; Nabora Soledad Reyes de Mochel | Zendy; Nathalie Gaudreault | Zendy; Victor Olivas | Zendy; Nikit Kumar | Zendy; Jessica M. Posada | Zendy; Andrew C. Birkeland | Zendy; Joseph H. Rapp | Zendy; Robert L. Raffaı̈ | Zendy

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Apolipoprotein E4 Domain Interaction Accelerates Diet-Induced Atherosclerosis in Hypomorphic Arg-61 Apoe Mice

Author(s) -

Delphine Eberlé,

Roy Kim,

Fu Sang Luk,

Nabora Soledad Reyes de Mochel,

Nathalie Gaudreault,

Victor Olivas,

Nikit Kumar,

Jessica M. Posada,

Andrew C. Birkeland,

Joseph H. Rapp,

Robert L. Raffaı̈

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.246389

Subject(s) - apolipoprotein e , apolipoprotein b , lipoprotein , cholesterol , medicine , chemistry , endocrinology , in vivo , biology , microbiology and biotechnology , immunology , genetics , disease

Apolipoprotein (apo) E4 is an established risk factor for atherosclerosis, but the structural components underlying this association remain unclear. ApoE4 is characterized by 2 biophysical properties: domain interaction and molten globule state. Substituting Arg-61 for Thr-61 in mouse apoE introduces domain interaction without molten globule state, allowing us to delineate potential proatherogenic effects of domain interaction in vivo.

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