A Novel mRNA Binding Protein Complex Promotes Localized Plasminogen Activator Inhibitor-1 Accumulation at the Myoendothelial Junction | Zendy

Katherine R. Heberlein | Zendy; Jenny Han | Zendy; Adam C. Straub | Zendy; Angela K. Best | Zendy; Christoph Kaun | Zendy; Johann Wojta | Zendy; Brant E. Isakson | Zendy

Open Access

A Novel mRNA Binding Protein Complex Promotes Localized Plasminogen Activator Inhibitor-1 Accumulation at the Myoendothelial Junction

Author(s) -

Katherine R. Heberlein,

Jenny Han,

Adam C. Straub,

Angela K. Best,

Christoph Kaun,

Johann Wojta,

Brant E. Isakson

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.246371

Subject(s) - messenger rna , plasminogen activator , binding domain , binding protein , biology , rna binding protein , microbiology and biotechnology , tumor necrosis factor alpha , activator (genetics) , plasminogen activator inhibitor 1 , binding site , gene , endocrinology , biochemistry

Plasminogen activator inhibitor-1 (PAI-1) has previously been shown to be key to the formation of myoendothelial junctions (MEJs) in normal and pathological states (eg, obesity). We therefore sought to identify the mechanism whereby PAI-1 could be selectively accumulated at the MEJ.

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