PDGF-Induced Migration of Vascular Smooth Muscle Cells Is Inhibited by Heme Oxygenase-1 Via VEGFR2 Upregulation and Subsequent Assembly of Inactive VEGFR2/PDGFRβ Heterodimers | Zendy

Caroline Cheng | Zendy; Remco Haasdijk | Zendy; Dennie Tempel | Zendy; Wijnand K. den Dekker | Zendy; Ihsan Chrifi | Zendy; Lau A.J. Blonden | Zendy; Esther H. M. van de Kamp | Zendy; Martine de Boer | Zendy; Petra E. Bürgisser | Zendy; Annemarie Noorderloos | Zendy; Joost A.P. Rens | Zendy; Timo L.M. ten Hagen | Zendy; Henricus J. Duckers | Zendy

Open Access

PDGF-Induced Migration of Vascular Smooth Muscle Cells Is Inhibited by Heme Oxygenase-1 Via VEGFR2 Upregulation and Subsequent Assembly of Inactive VEGFR2/PDGFRβ Heterodimers

Author(s) -

Caroline Cheng,

Remco Haasdijk,

Dennie Tempel,

Wijnand K. den Dekker,

Ihsan Chrifi,

Lau A.J. Blonden,

Esther H. M. van de Kamp,

Martine de Boer,

Petra E. Bürgisser,

Annemarie Noorderloos,

Joost A.P. Rens,

Timo L.M. ten Hagen,

Henricus J. Duckers

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.112.245530

Subject(s) - downregulation and upregulation , vascular smooth muscle , microbiology and biotechnology , heme oxygenase , platelet derived growth factor receptor , cell migration , vascular endothelial growth factor a , phosphorylation , kinase insert domain receptor , signal transduction , chemistry , biology , cancer research , cell , heme , vascular endothelial growth factor , receptor , growth factor , endocrinology , vegf receptors , biochemistry , smooth muscle , gene , enzyme

In cardiovascular regulation, heme oxygenase-1 (HO-1) activity has been shown to inhibit vascular smooth muscle cell (VSMC) proliferation by promoting cell cycle arrest at the G1/S phase. However, the effect of HO-1 on VSMC migration remains unclear. We aim to elucidate the mechanism by which HO-1 regulates PDGFBB-induced VSMC migration.

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