Binding of Oxidized Low-Density Lipoprotein on Circulating Platelets Is increased in Patients With Acute Coronary Syndromes and Induces Platelet Adhesion to Vascular Wall In Vivo—Brief Report | Zendy

Konstantinos Stellos | Zendy; Manuela Sauter | Zendy; Manuela Fahrleitner | Zendy; Juliane Grimm | Zendy; Dimitrios Stakos | Zendy; Fréderic Emschermann | Zendy; Victoria Panagiota | Zendy; Stephan Gnerlich | Zendy; Annegret Perk | Zendy; Tanja Schönberger | Zendy; Boris Bigalke | Zendy; Harald F. Langer | Zendy; Meinrad Gawaz | Zendy

Open Access

Binding of Oxidized Low-Density Lipoprotein on Circulating Platelets Is increased in Patients With Acute Coronary Syndromes and Induces Platelet Adhesion to Vascular Wall In Vivo—Brief Report

Author(s) -

Konstantinos Stellos,

Manuela Sauter,

Manuela Fahrleitner,

Juliane Grimm,

Dimitrios Stakos,

Fréderic Emschermann,

Victoria Panagiota,

Stephan Gnerlich,

Annegret Perk,

Tanja Schönberger,

Boris Bigalke,

Harald F. Langer,

Meinrad Gawaz

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.244707

Subject(s) - platelet , platelet adhesion , in vivo , lipoprotein , platelet activation , adhesion , medicine , low density lipoprotein , cardiology , chemistry , cholesterol , biology , organic chemistry , microbiology and biotechnology

Hyperlipidemia is associated with platelet hyperactivity. In the present study, we evaluated the binding of oxidized low-density lipoprotein (oxLDL) on the surface of circulating platelets in patients with stable coronary artery disease and acute coronary syndromes and its possible association with platelet activation. Furthermore, the role of oxLDL binding on platelet adhesion to collagen and endothelial cells in vitro as well as after carotid ligation in mice was investigated.

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