Intercellular Adhesion Molecule 1 Engagement Modulates Sphingomyelinase and Ceramide, Supporting Uptake of Drug Carriers by the Vascular Endothelium | Zendy

Daniel Serrano | Zendy; Tridib Kumar Bhowmick | Zendy; Rishi Chadha | Zendy; Carmen Garnacho | Zendy; Silvia Muro | Zendy

Open Access

Intercellular Adhesion Molecule 1 Engagement Modulates Sphingomyelinase and Ceramide, Supporting Uptake of Drug Carriers by the Vascular Endothelium

Author(s) -

Daniel Serrano,

Tridib Kumar Bhowmick,

Rishi Chadha,

Carmen Garnacho,

Silvia Muro

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.244186

Subject(s) - ceramide , sphingomyelin , intracellular , endothelium , microbiology and biotechnology , intercellular adhesion molecule 1 , chemistry , adhesion , acid sphingomyelinase , cell adhesion molecule , drug , intercellular adhesion molecule , pharmacology , biochemistry , cell adhesion , biology , membrane , endocrinology , apoptosis , organic chemistry

Engagement of intercellular adhesion molecule 1 (ICAM-1) on endothelial cells by ICAM-1-targeted carriers induces cell adhesion molecule-mediated endocytosis, providing intraendothelial delivery of therapeutics. This pathway differs from classical endocytic mechanisms and invokes aspects of endothelial signaling during inflammation. ICAM-1 interacts with Na(+)/H(+) exchanger NHE1 during endocytosis, but it is unclear how this regulates plasmalemma and cytoskeletal changes. We studied such aspects in this work.

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