Transition From Obesity to Metabolic Syndrome Is Associated With Altered Myocardial Autophagy and Apoptosis | Zendy

Zi-Lun Li | Zendy; John R. Woollard | Zendy; Behzad Ebrahimi | Zendy; John A. Crane | Zendy; Kyra L. Jordan | Zendy; Amir Lerman | Zendy; Shen-Ming Wang | Zendy; Lilach O. Lerman | Zendy

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Transition From Obesity to Metabolic Syndrome Is Associated With Altered Myocardial Autophagy and Apoptosis

Author(s) -

Zi-Lun Li,

John R. Woollard,

Behzad Ebrahimi,

John A. Crane,

Kyra L. Jordan,

Amir Lerman,

Shen-Ming Wang,

Lilach O. Lerman

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.244061

Subject(s) - insulin resistance , medicine , metabolic syndrome , endocrinology , dyslipidemia , autophagy , lipotoxicity , fibrosis , inflammation , cardiology , obesity , apoptosis , biology , biochemistry

Transition from obesity to metabolic-syndrome (MetS) promotes cardiovascular diseases, but the underlying cardiac pathophysiological mechanisms are incompletely understood. We tested the hypothesis that development of insulin resistance and MetS is associated with impaired myocardial cellular turnover.

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