Contribution of Platelet CX 3 CR1 to Platelet–Monocyte Complex Formation and Vascular Recruitment During Hyperlipidemia | Zendy

Otilia Postea | Zendy; Elena M. Vasina | Zendy; Sandra Cauwenberghs | Zendy; Delia Projahn | Zendy; Elisa A. Liehn | Zendy; Dirk Lievens | Zendy; Wendy Theelen | Zendy; Birgit K. Kramp | Zendy; Elena Butoi | Zendy; Oliver Soehnlein | Zendy; Johan W. M. Heemskerk | Zendy; Andreas Ludwig | Zendy; Christian Weber | Zendy; Rory R. Koenen | Zendy

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Contribution of Platelet CX ₃ CR1 to Platelet–Monocyte Complex Formation and Vascular Recruitment During Hyperlipidemia

Author(s) -

Otilia Postea,

Elena M. Vasina,

Sandra Cauwenberghs,

Delia Projahn,

Elisa A. Liehn,

Dirk Lievens,

Wendy Theelen,

Birgit K. Kramp,

Elena Butoi,

Oliver Soehnlein,

Johan W. M. Heemskerk,

Andreas Ludwig,

Christian Weber,

Rory R. Koenen

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.243485

Subject(s) - platelet , monocyte , chemokine , platelet activation , medicine , chemistry , endocrinology , vascular smooth muscle , receptor , smooth muscle

The chemokine receptor CX(3)CR1 is an inflammatory mediator in vascular diseases. On platelets, its ligation with fractalkine (CX(3)CL1) induces platelet activation followed by leukocyte recruitment to activated endothelium. Here, we evaluated the expression and role of platelet-CX(3)CR1 during hyperlipidemia and vascular injury.

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