Interleukin-1 Assembles a Proangiogenic Signaling Module Consisting of Caveolin-1, Tumor Necrosis Factor Receptor–Associated Factor 6, p38–Mitogen-Activated Protein Kinase (MAPK), and MAPK-Activated Protein Kinase 2 in Endothelial Cells | Zendy

Joanna Jagielska | Zendy; Piyushkumar R. Kapopara | Zendy; Gustavo Salguero | Zendy; Michaela Scherr | Zendy; Harald Schütt | Zendy; Karsten Grote | Zendy; Bernhard Schieffer | Zendy; Udo Bavendiek | Zendy

Open Access

Interleukin-1 Assembles a Proangiogenic Signaling Module Consisting of Caveolin-1, Tumor Necrosis Factor Receptor–Associated Factor 6, p38–Mitogen-Activated Protein Kinase (MAPK), and MAPK-Activated Protein Kinase 2 in Endothelial Cells

Author(s) -

Joanna Jagielska,

Piyushkumar R. Kapopara,

Gustavo Salguero,

Michaela Scherr,

Harald Schütt,

Karsten Grote,

Bernhard Schieffer,

Udo Bavendiek

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.243477

Subject(s) - mapk/erk pathway , microbiology and biotechnology , angiogenesis , gene silencing , caveolin 1 , small interfering rna , biology , caveolae , matrigel , signal transduction , p38 mitogen activated protein kinases , protein kinase a , cancer research , chemistry , kinase , transfection , biochemistry , gene

Interleukin-1β (IL-1β) is a major cytokine linking inflammation and angiogenesis in pathological vascular processes, such as atherosclerosis and tumor neoangiogenesis. However, signaling pathways mediating IL-1β-induced proangiogenic processes in endothelial cells (ECs) have barely been elucidated yet. Therefore, the present study investigated IL-1β-induced proangiogenic signaling in ECs.

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