Regulatory T-Cell Response to Apolipoprotein B100–Derived Peptides Reduces the Development and Progression of Atherosclerosis in Mice | Zendy

Olivier Herbin | Zendy; Hafid Aït-Oufella | Zendy; Wang Yu | Zendy; Gunilla Nordin Fredrikson | Zendy; Benjamin Aubier | Zendy; Nicolas Pérez | Zendy; Véronique Barateau | Zendy; Jan Nilsson | Zendy; Alain Tedgui | Zendy; Ziad Mallat | Zendy

Open Access

Regulatory T-Cell Response to Apolipoprotein B100–Derived Peptides Reduces the Development and Progression of Atherosclerosis in Mice

Author(s) -

Olivier Herbin,

Hafid Aït-Oufella,

Wang Yu,

Gunilla Nordin Fredrikson,

Benjamin Aubier,

Nicolas Pérez,

Véronique Barateau,

Jan Nilsson,

Alain Tedgui,

Ziad Mallat

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.242800

Subject(s) - immune system , ovalbumin , inflammation , apolipoprotein b , immunology , medicine , adjuvant , regulatory t cell , apolipoprotein e , t cell , il 2 receptor , disease , cholesterol

The immunoinflammatory response plays a critical role in the development and progression of atherosclerosis. Recent studies suggested an important role for regulatory T (Treg) cells in the inhibition of disease-related vascular inflammation. We hypothesized that induction of a specific Treg cell response to atherosclerosis-relevant antigens would be an attractive strategy to limit the development and progression of atherosclerosis through the promotion of immune tolerance.

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