Inhibition of Bone Morphogenetic Protein Signaling Reduces Vascular Calcification and Atherosclerosis | Zendy

Matthias Derwall | Zendy; Rajeev Malhotra | Zendy; Carol Lai | Zendy; Yuko Beppu | Zendy; Elena Aïkawa | Zendy; Jasbir Seehra | Zendy; Warren M. Zapol | Zendy; Kenneth D. Bloch | Zendy; Paul B. Yu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Inhibition of Bone Morphogenetic Protein Signaling Reduces Vascular Calcification and Atherosclerosis

Author(s) -

Matthias Derwall,

Rajeev Malhotra,

Carol Lai,

Yuko Beppu,

Elena Aïkawa,

Jasbir Seehra,

Warren M. Zapol,

Kenneth D. Bloch,

Paul B. Yu

Publication year - 2012

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.111.242594

Subject(s) - bone morphogenetic protein , calcification , bone morphogenetic protein 2 , medicine , microbiology and biotechnology , chemistry , biology , biochemistry , in vitro , gene

The expression of bone morphogenetic proteins (BMPs) is enhanced in human atherosclerotic and calcific vascular lesions. Although genetic gain- and loss-of-function experiments in mice have supported a causal role of BMP signaling in atherosclerosis and vascular calcification, it remains uncertain whether BMP signaling might be targeted pharmacologically to ameliorate both of these processes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research